Cenegenics Comprehensive Multi-Vitamin Mineral Formula contains a balanced combination of vitamins and minerals, including vitamins B, C, D, E, K, Calcium, Magnesium, Zinc, and several more key nutrients that are essential to overall health.
- Designed to promote optimal health genesis at the cellular level
- Helps balance daily nutritional needs
- Formulated to support a healthy environment for the heart, muscles, bones and skin
- Enhances nerve function, digestion, immune function and cellular repair
Suggested Usage: As a dietary supplement, take one packet by mouth twice daily, or as directed by a physician.
Comprehensive Formula contains a balanced combination of vitamins and minerals, including vitamins B, C, D, E, K, Calcium, Magnesium, Zinc, and several more key nutrients that are essential to overall health.
Are you one of the many Americans caught in the standard American diet that is low in fruits and vegetables and high in processed foods? If so, vital nutrients that stabilize energy and immunity are being depleted from your body. Dietary imbalances can weaken your body’s resistance to illness and degenerative ailments. Make sure your body is getting essential nutritional support with Comprehensive Formula, which includes essential vitamins and minerals to help balance your daily nutritional needs. Comprehensive Formula is formulated to support a healthy environment for the heart, muscles, bones, and skin, while also enhancing nerve function, digestion, immune function, and cellular repair.
Individuals need an adequate intake of vitamins and minerals to maintain important body functions. A balanced ratio of nutrients can be obtained through multivitamins; yet, studies have found most individuals do not receive the optimal amount of vitamins that are necessary for overall health.[i] Additionally, it is suggested that more physicians need to educate their patients on the importance of taking a quality multivitamin.[i]
Vitamin deficiencies can lead to many health ailments, especially among older adults. One study explained that older women taking vitamins, in combination with exercise and hormone therapy, lessened the development of health ailments.[ii]
An eight-week study reviewed the effects of a multivitamin or a placebo on the micronutrient status of 80 healthy, older adults (50 to 87 years old). Results indicated that a multivitamin increased the micronutrient status in the treatment group to reduce various health risks.[iii]
Furthermore, vitamins can deter the effects of aging skin. A research review explained that vitamin supplementation enhanced immunity in the skin to reduce inflammation and signs of aging.[iv]
A longitudinal study examined the relationship between low vitamin intake and cardiovascular ailments among 80,082 healthy women. After fourteen years, the follow-up indicated women that regularly took a multivitamin had the lowest risk for cardiovascular ailments. Folate and vitamin B6, found in the multivitamin treatment, were suggested to be particularly important to cardiovascular health.[v]
A large survey evaluated multivitamin use among 21,923 participants. The study found that one-third of the individuals took dietary supplements, in which individuals taking vitamins and minerals had fewer cardiovascular risks.[vi]
Individuals that receive adequate amounts of vitamins, minerals, fiber, and essential fatty acids are 60-70% less likely to develop abnormal cell growth in the breast, colon or prostate. Furthermore, optimum levels of nutrients decrease the risk of lung disorders by 40-50%.[vii]
A longitudinal study evaluated vitamin B6 and folate intake in relation to colon health among 37,916 healthy women. After ten years, researchers found that women taking optimum levels of vitamin B6 and folate were less likely to develop colon ailments, as women that did not take these nutrients were at significant risk for developing abnormal cell growth in the colon.[viii] A similar longitudinal study that recruited 88,756 healthy women found that individuals taking a multivitamin had fewer colon risks. Researchers concluded these effects could be specifically associated with the folic acid content that is found in multivitamins.[ix]
A cross-sectional survey found that multivitamin intake was related to bodyweight, as overweight individuals were less likely to take a multivitamin. Individuals with normal bodyweight recognized the importance of taking a multivitamin to maintain overall health.[x] Another study found that body mass was associated with micronutrient levels. Overweight adults had low micronutrient levels, when compared to normal weight individuals.[xi]
Research between multivitamin use and weight has been extended to improving infant birth weight. One study recruited pregnant women in poor communities to take a prenatal multivitamin, finding the nutrients lowered a woman’s risk of giving birth to an underweight infant. Therefore, the prenatal multivitamin improved an infant’s life expectancy.[xii]
Another study found that multivitamin supplementation contributed to weight gain in pregnant women with autoimmune ailments in sub-Saharan Africa. Researchers recruited 1,075 pregnant women to take a multivitamin, multivitamin with vitamin A, vitamin A alone, or a placebo. Results indicated weight gain was significantly greater among women taking a multivitamin during pregnancy, especially among subjects taking the multivitamin/vitamin A combination.[xiii]
As individuals age, muscle often deteriorates. Researchers suggest that a healthy diet, vitamin supplementation, and regular physical activity can inhibit the loss of muscle mass and strength that is commonly found in the aging population.[xiv]
One study recruited athletes to take a vitamin and mineral supplement or a placebo prior to and during an extreme running competition. Researchers found that athletes taking the multivitamin had greater nutrient values in their blood serum and lower levels of lipid peroxidation (oxidative stress) that is associated with intense athletic training.[xv]
Multivitamins can improve the immune response and overall physical health by increasing micronutrient availability.[xvi] One study recruited 1,078 pregnant women in sub-Saharan Africa with autoimmune ailments to take a multivitamin finding the supplement increased their immunity and deterred the effects of their autoimmune illness.[xvii]
A one-year study recruited 130 individuals with blood sugar ailments to take a daily multiple or a placebo, reporting a multivitamin reduced the incidence of infection among subjects in the treatment group. A multivitamin also reduced micronutrient deficiencies in the treatment group.[xviii]
Several nutrients contained in a daily multiple have been found to support emotional health. A six-month study gave a probiotic multivitamin or a placebo to 42 adults with stress and fatigue. Results indicated the supplement reduced exhaustion and the stress response, along with improving the immune system.[xix]
Furthermore, one study evaluated the relationship between a daily multiple and mood improvement. Researchers recruited 225 elderly patients with an acute illness and low mood to take a multivitamin or a placebo, finding the treatment group had a significant improvement in mood, as vitamin B12 serum levels increased in this group.[xx]
Dosage & Interactions
Suggested Use: As a dietary supplement, take one packet daily, or as directed by a physician.
Biotin – 30 to 1,000 mcg per day
Boron – Up to 3 mg per day
Calcium – Up to 1,200 mg per day
Choline – Up to 1,200 mg per day
Chromium – 50 to 200 mcg per day
Inositol – Up to 300 mg per day
Magnesium – Up to 350 mg per day
Manganese – Up to 10 mg per day
Molybdenum – 75 mcg to 250 mcg per day
Niacin – Up to 2 g per day
Pantothenic Acid – 10 to 50 mg per day
Riboflavin – Up to 100 mg per day in divided doses
Selenium – Up to 900 mcg per day
Thiamin – Up to 200 mg per day in divided doses
Vitamin A – Up to 10,000 IU per day
Vitamin B6 – 2 mg to 20 mg per day
Vitamin B12 – Up to 5,000 mcg per day
Vitamin C – Up to 3,000 mg per day
Vitamin D3 – 1,000 IU per day
Vitamin E – 100 mg to 400 mg per day (149 to 596 IU per day)
Vitamin K1 – Up to 500 mcg per day
Vitamin K2 – Up to 500 mcg per day
Zinc – Up to 30 mg per day
The maximum safe dosages of the nutrients in this formula have not been determined for children, pregnant or nursing women, or those with severe liver or kidney disease. As with all supplement regimens, please consult your physician prior to use.
Biotin – There are no known adverse reactions with proper supplementation.
Boron – There are no known adverse reactions with proper supplementation.
Calcium – Taking calcium without food may increase the risk of kidney stones. Mild upset stomach has been reported with calcium supplementation.
Choline – Nausea, diarrhea and dizziness may occur in large doses.
Chromium – There are no known adverse reactions with proper supplementation.
Inositol – Pregnant women should avoid inositol, as it may stimulate uterine contractions.
Magnesium – Diarrhea, nausea, or abdominal cramping have been reported in large doses. Pregnant women and nursing mothers should not take doses greater than 350 mg per day of magnesium. Individuals with myasthenia gravis should not take magnesium.
Manganese – Individuals with liver or kidney ailments should not take manganese.
Molybdenum – Individuals with gout or hyperuricemia should avoid doses greater than 75 mcg.
Niacin – Up to 2 g per day
Pantothenic Acid – Diarrhea may occur in large doses.
Riboflavin – High doses of Riboflavin (400 mg per day) can cause diarrhea and polyuria.
Selenium – Pregnant women and nursing mothers should avoid taking doses greater than the RDA amount of selenium (60 to 70 mcg per day). Excessively high doses of selenium can lead to dry hair, brittle nails, fatigue, irritability, nausea, and vomiting.
Thiamin – Pregnant women should avoid doses of thiamin greater than 3 mg per day.
Vitamin A – Pregnant women and nursing mothers should avoid vitamin A doses higher than 5,000 IU per day. High doses (greater than 10,000 IU per day) of vitamin A can cause acute or chronic toxicity.
Vitamin B6 – High doses of vitamin B6 can cause nausea, abdominal pain, vomiting, loss of appetite, and breast soreness.
Vitamin B12 – Individuals with Leber’s disease (eye problems) should not use.
Vitamin B Complex – Stomach upset may occur in large doses.
Vitamin C – Stomach upset including nausea, diarrhea, abdominal cramps may occur in large doses due to unabsorbed vitamin C passing through the intestines.
Vitamin D3 – Do not take vitamin D if you have lupus. Pregnant women and nursing mothers should avoid supplementing with doses higher than the RDA amount (400 IU), unless prescribed by a physician. Research indicates that the RDA amount of vitamin D is not enough to meet all of your body’s needs. To lower health risks associated with vitamin D deficiency, optimal levels may be reached by taking 1000 IU/day.[xxi] Though optimal amounts of vitamin D may seem high in comparison to the RDA standard, studies have found vitamin D toxicity is unlikely to occur in doses less than 10,000 IU (250 mcg)/day.[xxii],[xxiii]
Vitamin E – Stomach upset may occur in large doses. Individuals with blood clotting ailments or high blood pressure should consult their physician prior to supplementation. Pregnant women and nursing mothers should not take doses higher than the RDA amounts (15 mg or 22.4 IU). Excessive amounts of vitamin E may cause an upset stomach, headache, fatigue, or blurred vision.
Vitamin K1 – There are no known adverse reactions with proper supplementation.
Vitamin K2 – There are no known adverse reactions with proper supplementation.
Zinc – High doses of zinc can lead to copper deficiency or cause stomach upset.
Consult your physician before supplementing with Comprehensive Formula if you are taking the following medications.
Biotin – Antibiotics, Anticonvulsants
Boron – There are no known interactions with proper supplementation.
Calcium – Bisphosphonates, H2 blockers, Levothyroxine, Proton pump inhibitors, Quinolones, Tertracyclines, Vitamin D Analogues.
Choline – Methotrexate
Chromium – Beta-Blockers (may elevate cholesterol levels)
Inositol – There are no known interactions with proper supplementation.
Magnesium – Biphosphonates, Quinolones, Tetracyclines
Manganese – Antacids, Laxatives, Tetracycline
Molybdenum – Acetaminophen
Niacin – Alpha-blockers; Alpha-glucosidase inhibitors; Anti-diabetic medications; Calcium channel blockers; Cholestyramine; Colestipol; Coumadin (Warfarin); Ganglionic blocking agents; Gemfibrozil; Nicotine patch; Nitrates; NSAIDS; Statins.
Pantothenic Acid – There are no known interactions with proper supplementation.
Riboflavin – Cholestyramine, Chlorpromazine, Colestipol, Doxorubicin, Metoclopramide, Nucleoside reverse-transcriptase inhibitors, Oral Contraceptive Agents, Probenecid, Propantheline Bromide, Quinacrine, Tricylclic Antidepressants
Selenium – There are no known interactions with proper supplementation.
Thiamin – Loop diuretics (furosemide, ethacrynic acid, bumetanide)
Vitamin A – Cholestyramine, Colestipol, Mineral Oil, Oral Contraceptives, Orlistat, Retinoid Drugs
Vitamin B6 – Amiodarone, Carbamazepine, Cycloserine, Ethionamide, Fosphenytoin, Hydralazine, Isoniazid, Levodopa, Oral Contraceptives, Penicillamine, Phenelzine, Phenobarbital, Phenytoin, Theophylline, Valproic acid.
Vitamin B12 – Antibiotics, H2 blockers, Aminosalicylic Acid, Metformin, Nitrous oxide, Proton pump inhibitors (omeprazole, etc.) may all decrease vitamin B12 absorption.
Vitamin C – Aluminum-containing antacids, Aspirin (impairs vitamin C), Chemotherapeutic agents, Estrogen, or Indinavir.
Vitamin D3 – The following drugs may reduce vitamin D absorption: Orlistat; Cholestyramine; Ketoconazole; Colestipol; Phenobarbital; Phenytoin; Antacids with aluminum.
Vitamin E – Anticoagulants (Warfarin), Amiodarone, Anticonvulsants, Colestipol, Cyclosporine, Isoniazid, Neomycin, Orlistat, Sucralfate, Zivudine.
Vitamin K – Broad-spectrum antibiotics, Cephalosporins, Cholestyramine, Colstipol, Orlistat, Salicylates, Warfarin.
Zinc – Antibiotics block zinc absorption
[i] Fletcher RH, Fairfield KM. Vitamins for chronic disease prevention in adults: clinical applications. JAMA. 2002 Jun; 287(23):3127-3129.
[ii] La Croix A, Newton K, Leveille S, Wallace J. Healthy aging: A woman’s issue. West J Med. 1997 October; 167(4):220–232.
[iii] McKay D, Perrone G, Rasmussen H, Dallal G, et al. The effects of a multivitamin/mineral supplement on micronutrient status, antioxidant capacity and cytokine production in healthy older adults consuming a fortified diet. Journal of the American College of Nutrition. 2000; 19(5):613-621.
[iv] Boelsma E, Hendriks FJ, Roza L. Nutritional skin care: health effects of micronutrients and fatty acids. American Journal of Clinical Nutrition. 2001; 73(5):853-864.
[v] Rimm E, Willett W, Hu F, Sampson L, Colditz G, et al. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA. 1998; 279:359-364.
[vi] Harrison R, Holt D, Pattison D, Elton P. Are those in need taking dietary supplements? A survey of 21,923 adults. British Journal of Nutrition. 2004; 91(4):617-623.
[vii] Donaldson M. Nutrition and cancer: A review of the evidence for an anti-cancer diet. Nutr J. 2004; 3:19.
[viii] Zhang S, Moore S, Lin J, Cook N, et al. Folate, vitamin B6, multivitamin supplements, and colorectal cancer risk in women. Am J Epidemiol. 2006; 163(2):108-115.
[ix] Giovannucci E, Stampfer M, Colditz G, Hunter D, et al. Multivitamin use, folate, and colon cancer in women in the Nurses’ Health Study. Annals of Inter Med. 1998; 129(7):517-524.
[x] Kimmons J, Blanck H, Tohill B, Zhang J, et al. Multivitamin use in relation to self-reported body mass index and weight loss attempts. MedGenMed. 2006; 8(3):3.
[xi] Kimmons J, Blanck H, Tohill B, Zhang J, et al. Associations Between Body Mass Index and the Prevalence of Low Micronutrient Levels Among US Adults. MedGenMed. 2006; 8(4):59.
[xii]Scholl T, Hediger M, Bendich A, Schall J, et al. Use of Multivitamin/Mineral Prenatal Supplements: Influence on the Outcome of Pregnancy. Am J Epidemiol. 1997; 146:134-141.
[xiii] Villamor E et al. Effect of multivitamin and vitamin A supplements on weight gain during
pregnancy among HIV-1-infected women. American Journal of Clinical Nutrition, 2002; 76:1082-1090.
[xiv] Roubenoff R. Physical Activity, Inflammation, and Muscle Loss. Nutrition Reviews. 2007; 65(3):s208-s212.
[xv] Machefer G, Groussard C, Vincent S, Zouhal H, et al. Multivitamin-Mineral Supplementation Prevents Lipid Peroxidation during “The Marathon des Sables”. Journal of the American College of Nutrition. 2007; 26(2):111-120.
[xvi] Bendich A. Micronutrients in women’s health and immune function. Nutrition. 2001; 17(10): 858–867.
[xvii] Fawzi WW, Msamanga GI, Spiegelman D, et al. A randomized trial of multivitamin supplements and HIV disease progression and mortality. N Engl J Med. 2004; 351(1):23-32.
[xviii] Barringer T, Kirk J, Santaniello A, Foley K, Michielutte R. Effect of a Multivitamin and Mineral Supplement on Infection and Quality of Life. Annals of Intern Med. 2003; 138(5):365-371.
[xix] Gruenwald J, Graubaum H, Harde A. Effect of a probiotic multivitamin compound on stress and exhaustion. Advances in Therapy. 2002; 19(3):141-150.
[xx] Gariballa S, Forster S. Effects of dietary supplements on depressive symptoms in older patients: A randomised double-blind placebo-controlled trial. Clin Nutr. 2007; 26(5):545-551.
[xxi] Garland C, Garland F, Gorham E, et al. The role of vitamin D in cancer prevention. Amer J of Pub Health. 2006; 96(2):252-261.
[xxii] Peacock, M, Liu, G, Carey, M, et al. Effect of calcium or 25OH vitamin D3 dietary supplementation on bone loss at the hip in men and women over the age of 60. J Clin Endocrinol Metab. 2000; 85: 3011-3019.[xxiii] Hollis, BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr. 2005; 135: 317-322.
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